| 2021-23 Baseball Regions |
| Class 1A |
| School | Class | Region |
| Biggersville High School | 1 | 1 |
| Blue Mountain High School | 1 | 1 |
| Falkner High School | 1 | 1 |
| Jumpertown High School | 1 | 1 |
| Thrasher High School | 1 | 1 |
| Ingomar Attendance Center | 1 | 2 |
| Smithville High School | 1 | 2 |
| Tremont Attendance Center | 1 | 2 |
| Tupelo Christian | 1 | 2 |
| Wheeler High School | 1 | 2 |
| Ashland High School | 1 | 3 |
| Coldwater Attendance Center | 1 | 3 |
| H. W. Byers High School (9-12) | 1 | 3 |
| Hickory Flat Attendance Center | 1 | 3 |
| West Union Attendance Center | 1 | 3 |
| Hamilton High School | 1 | 4 |
| Houlka Attendance Center | 1 | 4 |
| Okolona High School | 1 | 4 |
| Vardaman High School | 1 | 4 |
| West Lowndes High School | 1 | 4 |
| Ethel Attendance Center | 1 | 5 |
| French Camp | 1 | 5 |
| Leake County High School | 1 | 5 |
| McAdams Attendance Center | 1 | 5 |
| Noxapater Attendance Center | 1 | 5 |
| Sebastopol Attendance Center | 1 | 5 |
| McEvans School | 1 | 6 |
| Simmons High School | 1 | 6 |
| South Delta High School | 1 | 6 |
| West Bolivar Dist High School | 1 | 6 |
| West Tallahatchie High School | 1 | 6 |
| Bay Springs High School | 1 | 7 |
| Enterprise School | 1 | 7 |
| Mount Olive Attendance Center | 1 | 7 |
| Taylorsville Attendance Center | 1 | 7 |
| Lumberton High School | 1 | 8 |
| Resurrection | 1 | 8 |
| Richton High School | 1 | 8 |
| Salem Attendance Center | 1 | 8 |
| Class 2A |
| School | Class | Region |
| Baldwyn High School | 2 | 1 |
| Belmont School | 2 | 1 |
| East Union Attendance Center | 2 | 1 |
| Myrtle Attendance Center | 2 | 1 |
| New Site High School | 2 | 1 |
| Pine Grove High School | 2 | 1 |
| Walnut Attendance Center | 2 | 1 |
| Potts Camp High School (9-12) | 2 | 2 |
| Bruce High School | 2 | 2 |
| Calhoun City High School | 2 | 2 |
| Charleston High School | 2 | 2 |
| J Z George High School | 2 | 2 |
| Leflore County High School | 2 | 2 |
| Coahoma County High School | 2 | 3 |
| Leland High School | 2 | 3 |
| M. S. Palmer High School | 2 | 3 |
| North Side High School | 2 | 3 |
| O’Bannon High School | 2 | 3 |
| Riverside High School | 2 | 3 |
| Strayhorn High School | 2 | 3 |
| Choctaw County High School | 2 | 4 |
| East Webster High School | 2 | 4 |
| Eupora High School | 2 | 4 |
| Kemper County High School | 2 | 4 |
| Nanih Waiya Attendance Center | 2 | 4 |
| Pelahatchie Attendance Center | 2 | 5 |
| Pisgah High School | 2 | 5 |
| Puckett Attendance Center | 2 | 5 |
| Velma Jackson High School | 2 | 5 |
| Lake High School | 2 | 6 |
| Newton High School | 2 | 6 |
| Philadelphia High School | 2 | 6 |
| Scott Central Attendance Center | 2 | 6 |
| Amite County High School | 2 | 7 |
| Bogue Chitto School | 2 | 7 |
| East Marion High School | 2 | 7 |
| Loyd Star School | 2 | 7 |
| West Lincoln School | 2 | 7 |
| Collins High School | 2 | 8 |
| Heidelberg High School | 2 | 8 |
| Mize Attendance Center | 2 | 8 |
| North Forrest High School | 2 | 8 |
| Sacred Heart | 2 | 8 |
| Stringer Attendance Center | 2 | 8 |
| Class 3A |
| School | Class | Region |
| Alcorn Central High School | 3 | 1 |
| Booneville High School | 3 | 1 |
| Kossuth High School | 3 | 1 |
| Mantachie Attendance Center | 3 | 1 |
| Water Valley High School | 3 | 1 |
| Byhalia High School | 3 | 2 |
| Holly Springs High School | 3 | 2 |
| Independence High School | 3 | 2 |
| North Panola High School | 3 | 2 |
| Rosa Fort High School | 3 | 2 |
| Amanda Elzy High School | 3 | 3 |
| Humphreys County High School | 3 | 3 |
| Thomas E. Edwards High School | 3 | 3 |
| Winona Secondary School | 3 | 3 |
| Yazoo County High School | 3 | 3 |
| Nettleton High School | 3 | 4 |
| Aberdeen High School | 3 | 4 |
| Amory High School | 3 | 4 |
| Hatley High School | 3 | 4 |
| Noxubee County High School | 3 | 4 |
| Union High School | 3 | 5 |
| Clarkdale High School | 3 | 5 |
| Enterprise High School | 3 | 5 |
| Forest High School | 3 | 5 |
| Morton High School | 3 | 5 |
| Southeast Lauderdale High School | 3 | 5 |
| Crystal Springs High School | 3 | 6 |
| Magee High School | 3 | 6 |
| McLaurin Attendance Center | 3 | 6 |
| Raleigh High School | 3 | 6 |
| St. Andrew’s | 3 | 6 |
| Wesson Attendance Center | 3 | 7 |
| Franklin High School | 3 | 7 |
| Hazlehurst High School | 3 | 7 |
| Jefferson Co High | 3 | 7 |
| Port Gibson High School | 3 | 7 |
| Tylertown High School | 3 | 7 |
| Jefferson Davis County | 3 | 8 |
| Perry Central High School | 3 | 8 |
| Seminary High School | 3 | 8 |
| St. Patrick | 3 | 8 |
| St. Stanislaus | 3 | 8 |
| West Marion High School | 3 | 8 |
| Class 4A |
| School | Class | Region |
| Corinth High School | 4 | 1 |
| Tishomingo County High School | 4 | 1 |
| Itawamba Agricultural High School | 4 | 1 |
| Mooreville High School | 4 | 1 |
| Shannon High School | 4 | 1 |
| Caledonia High School | 4 | 1 |
| New Albany High School | 4 | 2 |
| North Pontotoc High School | 4 | 2 |
| Ripley High School | 4 | 2 |
| Houston High School | 4 | 2 |
| Pontotoc High School | 4 | 2 |
| South Pontotoc High School | 4 | 2 |
| Clarksdale High School | 4 | 3 |
| Gentry High School | 4 | 3 |
| Greenwood High School | 4 | 3 |
| Senatobia Jr Sr High School | 4 | 3 |
| Yazoo City High School | 4 | 3 |
| Choctaw Central | 4 | 4 |
| Kosciusko Senior High School | 4 | 4 |
| Leake Central High School | 4 | 4 |
| Louisville High School | 4 | 4 |
| Northeast Lauderdale High School | 4 | 4 |
| West Lauderdale High School | 4 | 4 |
| Mendenhall High School | 4 | 5 |
| Newton County High School | 4 | 5 |
| Northeast Jones High School | 4 | 5 |
| Quitman High School | 4 | 5 |
| Richland High School | 4 | 5 |
| Lanier High School | 4 | 6 |
| McComb High School | 4 | 6 |
| North Pike Senior High School | 4 | 6 |
| Raymond High School | 4 | 6 |
| South Pike Senior High School | 4 | 6 |
| Wingfield High School | 4 | 6 |
| Columbia High School | 4 | 7 |
| Forrest County Agricultural | 4 | 7 |
| Lawrence County High School | 4 | 7 |
| Purvis High School | 4 | 7 |
| Sumrall High School | 4 | 7 |
| Poplarville Jr Sr High School | 4 | 7 |
| Greene County High School | 4 | 8 |
| Bay High School | 4 | 8 |
| Moss Point High School | 4 | 8 |
| Pass Christian High School | 4 | 8 |
| Stone High School | 4 | 8 |
| Class 5A |
| School | Class | Region |
| Saltillo High School | 5 | 1 |
| Columbus High School | 5 | 1 |
| New Hope High School | 5 | 1 |
| West Point High School | 5 | 1 |
| Lafayette High School | 5 | 2 |
| Lake Cormorant High | 5 | 2 |
| Cleveland Central High School | 5 | 2 |
| Greenville High School | 5 | 2 |
| Holmes County Central High School | 5 | 3 |
| Neshoba Central High School | 5 | 3 |
| Canton Public High School | 5 | 3 |
| Ridgeland High School | 5 | 3 |
| Callaway High School | 5 | 4 |
| Provine High School | 5 | 4 |
| Vicksburg High School | 5 | 4 |
| Forest Hill High School | 5 | 4 |
| Jim Hill High School | 5 | 4 |
| West Jones High School | 5 | 5 |
| Florence High School | 5 | 5 |
| Natchez High School | 5 | 5 |
| Brookhaven High School | 5 | 5 |
| Laurel High School | 5 | 6 |
| South Jones High School | 5 | 6 |
| Wayne County High School | 5 | 6 |
| Hattiesburg High School | 5 | 6 |
| Long Beach Senior High School | 5 | 7 |
| Pearl River Central High School | 5 | 7 |
| Picayune Memorial High School | 5 | 7 |
| West Harrison High School | 5 | 7 |
| George County High School | 5 | 8 |
| East Central High School | 5 | 8 |
| Gautier High School | 5 | 8 |
| Vancleave High School | 5 | 8 |
| Class 6A |
| School | Class | Region |
| Grenada High School | 6 | 1 |
| Oxford High School | 6 | 1 |
| Starkville High School | 6 | 1 |
| Tupelo High School | 6 | 1 |
| Center Hill High School | 6 | 2 |
| Desoto Central High School | 6 | 2 |
| Lewisburg High School | 6 | 2 |
| Olive Branch High School | 6 | 2 |
| Hernando High School | 6 | 3 |
| Horn Lake High | 6 | 3 |
| Southaven High School | 6 | 3 |
| South Panola High School | 6 | 3 |
| Clinton High School | 6 | 4 |
| Germantown High School | 6 | 4 |
| Madison Central High School | 6 | 4 |
| Murrah High School | 6 | 4 |
| Brandon High School | 6 | 5 |
| Meridian High School | 6 | 5 |
| Oak Grove High School | 6 | 5 |
| Petal High School | 6 | 5 |
| Northwest Rankin High School | 6 | 6 |
| Pearl High School | 6 | 6 |
| Terry High School | 6 | 6 |
| Warren Central High School | 6 | 6 |
| D’iberville High School | 6 | 7 |
| Ocean Springs High School | 6 | 7 |
| Pascagoula High School | 6 | 7 |
| St Martin High School | 6 | 7 |
| Biloxi High School | 6 | 8 |
| Gulfport High School | 6 | 8 |
| Hancock High School | 6 | 8 |
| Harrison Central High School | 6 | 8 |
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