Mississippi High School Activities Association The place for high school sports in Mississippi MHSAA 2021 Regional Bowling Sites
| Class 1 Region 1 | Plaza Lanes (Corinth) | January 29 | |
| Class 1 Region 2 | Plaza Lanes (Corinth) | January 27 | |
| Class 1 Region 3 | Spanish Trail Lanes (Gautier) | January 27 | |
| Class 2 Region 1 | Harmony Family (Cleveland) | January 25 | |
| Class 2 Region 2 | Spinners (Florence) | January 28 (boys) January 29 (girls) | |
| Class 2 Region 3 | Spanish Trail Lanes (Gautier) | January 26 (girls) | |
| January 27 (boys) | |||
| Class 3 Region 1 | Strike Zone (Southaven) | January 29 | |
| Class 3 Region 2 | Fannin Lanes (Brandon) | January 29 | |
| Class 3 Region 3 | Cypress Lanes (D’Iberville) | January 27 (boys) | |
| Park 10 (Diamond Head) | January 29 (girls) | ||
| Host Schools: | |||
| Class 1 Region 1 | Kossuth HS | ||
| Class 1 Region 2 | Mantachie HS | ||
| Class 1 Region 3 | Resurrection Catholic HS | ||
| Class 2 Region 1 | Cleveland Central HS | ||
| Class 2 Region 2 | Richland HS | ||
| Class 2 Region 3 | Vancleave HS | ||
| Class 3 Region 1 | Lewisburg HS | ||
| Class 3 Region 2 | Madison Central HS | ||
| Class 3 Region 3 | D’Iberville HS | ||
| Hancock HS |
